Preheat oven to 375 degrees. Spray 9 x 13 or larger baking sheet with non-stick cooking spray or line with foil or parchment paper. Set aside.
Using a sharp knife or bone-cutting shears, remove wing tips and discard. Cut wings at the joint, leaving the drumette and the wingette.
Measure the flour, garlic powder and onion powder into a large food storage bag. Shake bag until combined.
In a shallow bowl crack the eggs and whisk until frothy. Into another shallow bowl or plate, pour the tortilla chip crumbs.
Working a few at a time, drop wings into bag with flour mixture and shake to coat. Tap off excess.
Dip wings into the egg mixture, turning to coat. Roll wings in tortilla crumbs until completely covered. Arrange the chicken wing pieces into a single layer on baking sheet.
Bake on the middle rack of 375 degree oven for 45 – 55 minutes or until wings have reached an internal temperature of 165°F on a meat thermometer. Serve Hot.